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Bachelor/Master Thesis Microphysiological in vitro model of the liver(m/w/d)

The Natural and Medical Sciences Institute (NMI) at the University of Tübingen is a non-profit research institute of the "Innovationsallianz Baden-Württemberg": the NMI performs applied research at the interface between life science and material science. A position for a Bachelor/Master thesis in Biology, Biochemistry, Biomedical Engineering, Medical Technology or Biophysics, is available for an immediate start in the working group BioMEMS & Sensors Group.

Motivation and background

At the NMI, BioMEMS & Sensors Group, we develop Microphysiological Systems (MPS) for applications in drug development and personalized medicine. The convergence of cell biology and microfluidics enables fundamentally new in vitro test systems, representing the smallest functional units of organs. These systems may be continuously perfused and ultimately used for drug testing. By closely mimicking the smallest functional units of organs, scientists envision significantly improved predictivity with respect to drug effects and toxicity when compared to conventional test systems.

The HepaChip-MWP (see figure) represents a MPS in multiwellplate format comprising 24 liver sinusoids assembled from primary liver cells. These micro-tissues are cultivated under flow closely mimicking in vivo conditions. Cell assembly by dielectrophoresis is performed using a robotic system in order to achieve a high degree of robustness and reproducibility of this culture system.

Objectives of the thesis

  • Assembly and culture of liver sinusoids, including co-culture with non-parenchymal cell types
  • Assessment of metabolic activity
  • Analysis of protein expression and liver typical zonation
  • Drug testing

Requirements

  • Education in Biology, Biochemistry, Biomedical Technology, Biophysics or similar, aptitude
  • practical knowledge in cell biology procedures and typical assays

We offer

A thesis within an exciting multidisciplinary project and a highly innovative research topic, careful supervision in an inspiring environment, up to date equipment.

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Your contact person

Ms Katja Rösslein

Contact

NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen
Markwiesenstraße 55
72770 Reutlingen

Phone: +49 7121 5153070
E-Mail: bewerbung@nmi.de