Research Associate (m/f/d) with the possibility to pursue a Ph.D. in the field of stem cell-derived disease models (65%) in Reutlingen
Excellent research with a view to practical application: That is our claim at the NMI Natural and Medical Sciences Institute in Reutlingen! We are a non-university research institute at the interface of biosciences and materials science. With our unique, interdisciplinary range of expertise, we are a strong partner in the field of research and development as well as by providing services for regional and international companies. Our services are aimed at companies in the healthcare industry as well as in vehicle, machine and tool construction and cover the broad spectrum of materials technology and quality control.
The Cell and Molecular Biology team conducts research in collaboration with academic, clinical, and industrial partners. To strengthen our team, we are looking for a Research Associate (m/f/d) with a 65% employment level (possibility to pursue a Ph.D.) - as part of a funded consortium project, in which we aim at developing and functionally characterising an hiPSC-derived 2D/3D model of Parkinson's disease.
Your tasks
- Analysis and elucidation of alpha-synuclein-dependent molecular pathological processes and phenotypes of Parkinson's disease with a focus on mitochondrial function and integrity as well as on neuronal viability and function
- Use and, if necessary, establishment of optogenetic and imaging/microscopic methods
- Establishment of workflows to support scSeq analyses
- Practical support of a funded consortium project to elucidate neurobiological mechanisms of emotional cognition
- Preparation and provision of lentiviral preparations as well as processing and immunohistochemical/microscopic analysis of tissue samples obtained from consortium partners
- Practical support of the cell and molecular biology team in the cultivation and maintenance of hiPSC cultures for use in various projects
- Guidance and supervision of interns and student employees in the processing of research projects
Requirements
- University degree in neuroscience or a related subject
- Confident application of standard molecular biology methods
- Proven practical experience in the establishment and maintenance of eukaryotic cell cultures
- Proven practical experience in histological tissue processing for the preparation of sections and immunocytochemistry/histochemistry
- Basic knowledge and initial practical experience in the handling, passage, and maintenance of human iPSCs and derived cell types
- Basic knowledge of the molecular pathology of Parkinson's disease
- Knowledge of the functioning of and formation, maintenance, and stabilisation of neuronal synapses
- Understanding of and initial experience with fluorescence microscopy methods including confocal microscopy
- Interest in working under conditions of genetic engineering safety level 2 (e.g. preparation of recombinant lentiviral suspensions)
- Proactive, collegial cooperation and the ability to present results in multidisciplinary and heterogeneous project teams are required
We offer
- Working within an exciting multidisciplinary project and a highly innovative research topic
- Highly motivated, competent and multidisciplinary team with scientific and technical staff
- Excellent infrastructure and technical equipment
- An exciting and dynamic working environment in application-oriented research institut
- Recruitment and remuneration are in accordance with TV-L (collective agreement of the Länder)
- Work-life balance through flexible working hours and mobile working
- Company pension scheme (VBL)
- Free employee parking in the multi-storey car park
- Attractive "bridge day" arrangement as well as paid days off on 24/31 December
- Staff events and excursions
Interested? Click on "Apply now", the online application takes just two minutes.
Your contact person
Ramona Stiel
Contact us
NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen
Markwiesenstraße 55
72770 Reutlingen
+49 7121 51530111